Zaltoprofen (ZPF) is a non steroidal anti inflammatory analgesic which has excellent effect in rheumatoid arthritis. It shows excellent GI safety as compare to other NSAIDs. Colon targeting drug delivery system specifically delivering drug to the colon, many advantages like improving safety and reducing toxicity when treating local or systemic chronic diseases. To formulate and evaluate colon targeting drug delivery system for the better treatment of rheumatoid arthritis. To study the effect of different hydrogel plug polymers on in-vitro release of ZPF from colon targeting capsule. To carry out stability study of the selected formulation. It may increase bioavailability of the drug. Identification of drug was done by using various testing method. Compatibility studies of drug and polymer were performed by FTIR spectroscopy and DSC. The microcapsule of ZPF was prepared by using different ratios of ZPF and Eudragit S100 and emulsification-solvent evaporation as a method of preparation. FTIR spectroscopy and DSC study revealed that there were no possible interaction between drug and excipients. Microcapsules batch A2 was optimized batch having higher flow property, drug entrapment and % drug release were found and follows Korsmeyer-Peppas model.
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